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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
16.67
Human Site:
S131
Identified Species:
26.19
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
S131
G
L
Q
V
D
L
Q
S
D
G
A
A
A
E
D
Chimpanzee
Pan troglodytes
XP_528129
863
96543
S131
G
L
Q
V
D
L
Q
S
D
G
A
A
A
E
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
T197
G
L
Q
V
D
L
Q
T
E
V
P
A
T
E
D
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
D131
L
Q
V
D
L
Q
S
D
G
A
A
A
E
D
I
Rat
Rattus norvegicus
NP_387500
862
96552
D131
L
Q
V
D
L
Q
S
D
G
A
A
A
E
D
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
S131
G
R
Q
V
D
L
H
S
D
G
P
A
A
D
D
Chicken
Gallus gallus
XP_424376
859
96866
P131
V
D
L
H
S
D
G
P
A
E
D
L
V
T
A
Frog
Xenopus laevis
P30664
863
97105
S131
V
K
Q
V
D
L
H
S
D
Q
P
A
A
E
E
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
P85
S
S
R
V
E
G
T
P
R
S
G
I
R
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
P133
G
S
G
L
E
P
I
P
E
K
G
S
E
T
T
Honey Bee
Apis mellifera
XP_624670
636
71159
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
K94
K
L
R
K
F
P
G
K
V
L
P
A
L
E
E
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
S173
I
R
Q
V
N
L
G
S
D
Q
T
G
E
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
L51
I
Q
V
D
L
D
D
L
F
N
Y
K
D
E
S
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
G182
E
P
L
R
I
I
W
G
T
N
V
S
I
Q
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
66.6
N.A.
13.3
13.3
N.A.
73.3
0
60
6.6
N.A.
6.6
0
20
33.3
P-Site Similarity:
100
100
N.A.
80
N.A.
20
20
N.A.
80
0
66.6
20
N.A.
33.3
0
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
7
14
27
54
27
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
20
34
14
7
14
34
0
7
0
7
20
27
% D
% Glu:
7
0
0
0
14
0
0
0
14
7
0
0
27
40
20
% E
% Phe:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
34
0
7
0
0
7
20
7
14
20
14
7
0
7
0
% G
% His:
0
0
0
7
0
0
14
0
0
0
0
0
0
0
0
% H
% Ile:
14
0
0
0
7
7
7
0
0
0
0
7
7
0
7
% I
% Lys:
7
7
0
7
0
0
0
7
0
7
0
7
0
0
0
% K
% Leu:
14
27
14
7
20
40
0
7
0
7
0
7
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
14
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
14
0
20
0
0
27
0
0
7
0
% P
% Gln:
0
20
40
0
0
14
20
0
0
14
0
0
0
7
0
% Q
% Arg:
0
14
14
7
0
0
0
0
7
0
0
0
7
0
0
% R
% Ser:
7
14
0
0
7
0
14
34
0
7
0
14
0
0
7
% S
% Thr:
0
0
0
0
0
0
7
7
7
0
7
0
7
14
20
% T
% Val:
14
0
20
47
0
0
0
0
7
7
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _